These two images were taken by the same photographer (Stuart Thomson), the camera is facing the same direction (northwest), and are of nearly the same locations (Seymour Street at Nelson in the first image; Seymour from a bit south of Nelson in the second).
The 1920 image was one of two made by Thomson of an automobile wreck on the corner (the second image looks west down Nelson, toward Granville), possibly for an auto insurance client of Thomson’s. The occurrence of auto accidents was apparently still sufficiently uncommon that it could draw a crowd of pedestrian rubber-kneckers on a miserable day. The 1926 image was made by Thomson for an advertising client, Duker & Shaw Billboards.
It is remarkable, to me, how dramatically this section of Seymour Street had changed in the approximately six years that passed between the creation of the two images. In the 1920 photo, the property on the northwest corner of Seymour and Nelson was a single family dwelling (albeit, one that appears to have been for sale) and the neighbouring properties appear likewise to be family homes. In the 1926 image, Nelson Street crosses Seymour about mid-way up the image. You can just make out the end of the name of the business then located at the northwest corner of Seymour and Nelson: Boultbee Motors. The neighbours of Boultbee appear to be other businesses and the anchor at the end of the block (at southwest corner Seymour at Smithe) is Vancouver Motors (the building in which the Staples stationery store is located today).
For different/later images of Seymour and Nelson, see this post.